Labs-Mart provides dioxin, furan, and PCB assays by GC-HRMS (EPA 1613 Revision B). The detection limits for PCDF and PCDD are 0.40 pg/g and 0.20 pg/g, respectively.

  • Polychlorinated dibenzo-p-dioxins (PCDDs), or simply dioxins, are derivatives of dibenzo-p-dioxin,  There are 75 PCDDs, and seven of them are specifically toxic and assayed.

dioxin

The general chemical structure of polychlorinated dibenzodioxins (dioxin) where n and m are whole numbers from 0 to 4

  • Polychlorinated dibenzofurans (PCDFs), or furans, are derivatives of dibenzofuran.  There are 135 PCDF congeners or derivatives that differ only in the number and location of chlorine atoms.  There are also ten PCDFs which are chemically not dioxins but instead have “dioxin-like” properties and are therefore largely considered equivalent to dioxins and subsequently assayed the same.

furans

General chemical structure of PCDFs

  • PCBs are assayed by GC-HRMS (EPA 1668B) with a detection limit of 5.0pg/g. Alternatively, PCBs can be assayed by GC-ECD (ASTM D4059) with a detection limit of 1.0 ppm.

pcb

Polychlorinated biphenyl structure

World Health Organization (WHO) and United States Food and Drug Administration (USFDA) Toxic Equivalence Factors (TEF) for the dioxin-like congeners of concern:

Polychlorinated dioxins (PCD) TEQ
2,3,7,8-TCDD 1
1,2,3,7,8-PeCDD 1
1,2,3,4,7,8-HxCDD 0.1
1,2,3,6,7,8-HxCDD 0.1
1,2,3,7,8,9-HxCDD 0.1
1,2,3,4,6,7,8-HpCDD 0.01
1,2,3,4,6,7,8,9-Octachlorooxanthrene (OCDD) 0.0003
Polychlorinated dibenzofurans (PCDF)
2,3,7,8-TCDF 0.1
1,2,3,7,8-PeCDF 0.03
2,3,4,7,8-PeCDF 0.3
1,2,3,4,7,8-HxCDF 0.1
1,2,3,6,7,8-HxCDF 0.1
1,2,3,7,8,9-HxCDF 0.1
2,3,4,6,7,8-HxCDF 0.1
1,2,3,4,6,7,8-HpCDF 0.01
1,2,3,4,7,8,9-HpCDF 0.01
OCDF 0.0003
Non-ortho-substituted PCBs
3,3′,4,4′-TCB (PCB77) 0.0001
3,4,4′,5-TCB (PCB81) 0.0003
3,3′,4,4′,5-PeCB (PCB126) 0.1
3,3′,4,4′,5,5′-HxCB (PCB169) 0.03
Mono-ortho-substituted PCBs
2,3,3′,4,4′-PeCB (PCB105) 0.00003
2,3,4,4′,5-PeCB (PCB114) 0.00003
2,3′,4,4′,5-PeCB (PCB118) 0.00003
2′,3,4,4′,5-PeCB (PCB123) 0.00003
2,3,3′,4,4′,5-HxCB (PCB156) 0.00003
2,3,3′,4,4′,5′-HxCB (PCB157) 0.00003
2,3′,4,4′,5,5′-HxCB (PCB167) 0.00003
2,3,3′,4,4′,5,5′-HpCB (PCB189) 0.00003